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The OWLQOL was designed to complete a full battery of patient-reported outcomes employing different concepts and different types of patient-reported outcome measures. The OWLQOL is intended to be used together and alongside other patient-reported outcomes of functional status, adherence to diet and treatment, and satisfaction with treatment. The OWLQOL measures a person’s global evaluation of position in life related to weight, weight loss, and weight-loss treatment. By using these and other patient-reported outcomes, investigators can address the experience of being overweight and obese and of weight loss on a broad spectrum of issues important to patients, their families, clinicians, regulators, payers, and society in general. The 17 items on the OWLQOL are used with equal weight to derive a single quality of life score.