1. Lipid profile / Triglycerides |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
-0.25 [-0.84, 0.34] |
Low |
It may result in little to no difference in triglycerides (mmol/L) |
0 |
0 |
[, ] |
NA |
2.0 |
-0.25 [-0.84, 0.34] |
Low |
2. Lipid profile / LDL-Cholesterol |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
-11.93 [-19.74, -4.12] |
Moderate |
It likely results in little to no difference in LDL levels (mg/dL) |
0 |
0 |
[, ] |
NA |
1.0 |
-11.93 [-19.74, -4.12] |
0 |
3. Lipid profile / HDL-Cholesterol (mmol) |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
5.49 [1.1, 9.87] |
Very low |
It may result in a large decrease in HDL levels (mmol/L) |
0 |
0 |
[, ] |
NA |
1.0 |
5.49 [1.1, 9.87] |
Low |
4. Lipid profile / Total cholesterol |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
-16.69 [-26.35, -7.03] |
Low |
It may result in little to no difference in total cholesterol (mg/dL) |
0 |
0 |
[, ] |
NA |
1.0 |
-16.69 [-26.35, -7.03] |
Low |
5. HbA1C / Glycated hemoglobin (HbA1c) |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
-1.42 [-2.02, -0.82] |
Low |
It may result in a large reduction in HbA1C levels (%) |
0 |
0 |
[, ] |
NA |
2.0 |
-1.42 [-2.02, -0.82] |
Low |
Footnotes per outcome:
1) a) Number of studies included in the network: 171 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 2 comparison(s). The range of follow up was from 1 to 96 months for the studies included in the whole network; b) We rated down the certainty of evidence due to serious risk of bias 2) a) We rated down the certainty of evidence due to serious risk of bias; b) Number of studies included in the network: 171 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 1 to 96 months for the studies included in the whole network. 3) a) We rated down the certainty of evidence due to serious riks of bias and serious imprecision; b) Number of studies included in the network: 162 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 1 to 96 months for the studies included in the whole network. 4) a) Number of studies included in the network: 176 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 1 to 96 months for the studies included in the whole network; b) We rated down the certainty of evidence due to very serious risk of bias 5) a) We rated down the certainty of evidence due to very serious risk of bias; b) Number of studies included in the network: 463 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 2 comparison(s). The range of follow up was from 1 to 96 months for the studies included in the whole network.
References of studies informing direct evidence:
N/A
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