1. Hospital admissions / HF-related hospital admissions |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Relative effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Relative effects (95% CI) - Difference |
Certainty of the evidence |
-7.600000000000009 [-15.917825112107646, 13.566255605381183] |
Very low |
It may have little to no effect in HF-related hospital admissions but the evidence is very uncertain |
1 |
0 |
-0.54 [-1.55, 0.47] |
Moderate |
1.0 |
0.16 [-2.34, 2.65] |
Moderate |
2. Hospital admissions / All-cause hospital admissions |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Relative effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Relative effects (95% CI) - Difference |
Certainty of the evidence |
-26.885185185185176 [-48.41666666666666, 22.918518518518507] |
Very low |
It may have little to no effect on all cause admission but the evidence is very uncertain |
1 |
0 |
-0.15 [-1.09, 0.79] |
Moderate |
1.0 |
-2.05 [-3.9, -0.19] |
Moderate |
3. Mortality / All causes of mortality |
NMA |
Direct |
Indirect |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Relative effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Relative effects (95% CI) - Difference |
Certainty of the evidence |
-30.712947658402175 [-97.12396694214864, 131.33223140495852] |
Very low |
It may decrease mortality but the evidence is very uncertain |
1 |
300 |
2.0339912586467506 [0.6065306597126334, 6.889510241581292] |
Moderate |
1.0 |
0.2592402606458915 [0.069252225309346, 0.9607894391523232] |
Moderate |
Footnotes per outcome:
1) a)We rated down the certainty of evidence due to serious risk of bias, very serious imprecision; b)Number of studies included in the network: 33 RCTs; Number of studies directly comparing the intervention with usual care: 1 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network. The range of follow-up was 12 months in the studies directly comparing the self-management intervention versus usual care. 2) a)We rated down the certainty of evidence due to serious risk of bias and very serious imprecision; b)Number of studies included in the network: 45 RCTs; Number of studies directly comparing the intervention with usual care: 1 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network. The range of follow-up was 12 months in the studies directly comparing the self-management intervention versus usual care. 3) a)We rated down due to very serious imprecision; b)Number of studies included in the network: 82 RCTs; Number of studies directly comparing the intervention with usual care: 1 RCT(s) (N=150); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network. The range of follow-up was 12 months in the studies directly comparing the self-management intervention versus usual care.
References of studies informing direct evidence:
1) Wagenaar-2018 2) Wagenaar-2018 3) Wagenaar-2018
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