| 1. Comorbidities managament / Systolic pressure |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| 0.05 [-7.22, 7.31] |
Very low |
It may result in little to no difference in systolic pressure |
0 |
0 |
[, ] |
N/A |
2.0 |
0.05 [-7.22, 7.31] |
Low |
| 2. Weight management / Waist size |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| 0.68 [-3.74, 5.11] |
Moderate |
It likely results in little to no difference on waist size |
0 |
0 |
[, ] |
N/A |
1.0 |
0.68 [-3.74, 5.11] |
Low |
| 3. Comorbidities managament / Diastolic pressure |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| 0.39 [-4.55, 5.32] |
Very low |
It may have little to no effect on diastolic pressure but the evidence is very uncertain |
0 |
0 |
[, ] |
N/A |
1.0 |
0.39 [-4.55, 5.32] |
Low |
| 4. Quality of life-Physical and psychological functioning / Depression |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| -0.05 [-0.6, 0.51] |
Very Low |
It may have little to no effect on depression but the evidence is very uncertain |
1 |
81 |
-0.05 [-0.6, 0.51] |
Low |
1.0 |
N/A |
NA |
| 5. Quality of life-Physical and psychological functioning / Quality of Life |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| -0.05 [-0.63, 0.54] |
Very low |
It may result in little to no difference in quality of life but the evidence is very uncertain |
1 |
92 |
-0.05 [-0.63, 0.54] |
Low |
N/A |
NA [NA, NA] |
Low |
| 6. Coping with the disease |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| 0.07 [-0.63, 0.76] |
Very Low |
It may have little to no effect on Coping with the disease but the evidence is very uncertain |
1 |
93 |
0.07 [-0.63, 0.76] |
Low |
0.0 |
N/A |
Low |
| 7. Weight management / BMI - Body Mass Index |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| -0.32 [-1.35, 0.7] |
Low |
It may result in little to no difference in Body mass index |
1 |
100 |
-0.85 [-2.56, 0.86] |
Low |
3.0 |
-0.03 [-1.31, 1.24] |
Low |
| 8. Weight management / Weight (Kgs/lbs) |
| NMA |
Direct |
Indirect |
| Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Interpretation of findings |
Number of studies |
Number of patients |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
Number of comparisons informing indirect evidence |
Anticipated absolute effects (95% CI) - Difference |
Certainty of the evidence |
| -0.82 [-3.16, 1.51] |
Very low |
It may have little to no effect on weight but the evidence is very uncertain |
2 |
193 |
-0.67 [-4.15, 2.82] |
Very low |
4.0 |
-0.94 [-4.09, 2.2] |
Low |
Footnotes per outcome:
1) a)We rated down the certainty of evidence due to, serious risk of biad and very serious imprecision;b)Number of studies included in the network: 8 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 2 comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network.
2) a) We rated down the certainty of evidence due to serious risk of bias; b) Number of studies included in the network: 178 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 1 comparison(s).
3) a)We rated down the certainty of evidence due to serious risk of bias, very serious imprecision; b)Number of studies included in the network: 112 RCTs; Number of studies directly comparing the intervention with usual care: 0 RCT(s) (N=0); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 1 to 96 months for the studies included in the whole network. The range of follow-up was months in the studies directly comparing the self-management intervention versus usual care.
4) a) Number of studies included in the network: 13 RCTs; Number of studies directly comparing the intervention with usual care: 1 RCT(s) (N=39); Number of comparison(s) informing the indirect estimate: 1 comparison(s). The range of follow up was from 2 to 24 months for the studies included in the whole network. The range of follow-up was 4 months in the studies directly comparing the self-management intervention versus usual care.; b) We rated down the certainty of evidence due to very imprecision and very serious risk of bias
5) a)We rated down the certainty of evidence due to very serious risk of bias and very serious imprecision; b)Number of studies included in the network: 22 RCTs; Number of studies directly comparing the intervention with usual care: 1 RCT(s) (N=47); Number of comparison(s) informing the indirect estimate: comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network. The range of follow-up was 4 months in the studies directly comparing the self-management intervention versus usual care.
6) a) We rated down the certainty of evidence due to very serious risk of bias and very serious imprecision;b) Number of studies included in the network: 14RCTs; Number of studies directly comparing the intervention with usual care: 1 RCT(s) (N=47); Number of comparison(s) informing the indirect estimate: 0 comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network. The range of follow-up was 4 months in the studies directly comparing the self-management intervention versus usual care.
7) a)We rated down the certainty of evidence due to very serious risk of bias; b)Number of studies included in the network: 222 RCTs; Number of studies directly comparing the intervention with usual care: 1 RCT(s) (N=50); Number of comparison(s) informing the indirect estimate: 3 comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network. The range of follow-up was 2 months in the studies directly comparing the self-management intervention versus usual care.
8) a) We rated down the certainty of evidence due to very serious of risk of bias and serious inconsistency; b) Number of studies included in the network: 329 RCTs; Number of studies directly comparing the intervention with usual care: 2 RCT(s) (N=97); Number of comparison(s) informing the indirect estimate: 4 comparison(s). The range of follow up was from 1 to 24 months for the studies included in the whole network. The range of follow-up was 2-4 months in the studies directly comparing the self-management intervention versus usual care.
References of studies informing direct evidence:
4) Gagnon-Girouard-2010
5) Gagnon-Girouard-2010
6) Gagnon-Girouard-2010
7) Mirkarimi-2015
8) Gagnon-Girouard-2010, Mirkarimi-2015
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