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A primer on network meta-analysis with emphasis on mental health
A primer on network meta-analysis with emphasis on mental health
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- 27-1-23 10:17 door Marta Ballester
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- 27-1-23 10:16 door Marta Ballester
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- A primer on network meta-analysis with emphasis on mental health
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Versie 1.1Door Marta Ballester, over 27-1-23 10:17Geen wijzigingslogboek
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Versie 1.0Door Marta Ballester, over 27-1-23 10:16Geen wijzigingslogboek
Samenvatting
Objective: A quantitative synthesis of evidence via standard pair-wise meta-analysis lies on the top of the hierarchy for evaluating the relative
effectiveness or safety between two interventions. In most healthcare problems, however, there is a plethora of competing interventions. Network
meta-analysis allows to rank competing interventions and evaluate their relative effectiveness even if they have not been compared in an individual
trial. The aim of this paper is to explain and discuss the main features of this statistical technique.
Methods: We present the key assumptions underlying network meta-analysis and the graphical methods to visualise results and information in the
network. We used one illustrative example that compared the relative effectiveness of 15 antimanic drugs and placebo in acute mania.
Results: A network plot allows to visualise how information flows in the network and reveals important information about network geometry.
Discrepancies between direct and indirect evidence can be detected using inconsistency plots. Relative effectiveness or safety of competing
interventions can be presented in a league table. A contribution plot reveals the contribution of each direct comparison to each network estimate.
A comparison-adjusted funnel plot is an extension of simple funnel plot to network meta-analysis. A rank probability matrix can be estimated to
present the probabilities of all interventions assuming each rank and can be represented using rankograms and cumulative probability plots.
Conclusions: Network meta-analysis is very helpful in comparing the relative effectiveness and acceptability of competing treatments. Several
issues, however, still need to be addressed when conducting a network meta-analysis for the results to be valid and correctly interpreted.
Het COMPAR-EU project heeft financiering ontvangen van het Horizon 2020 onderzoeks- en innovatieprogramma van de Europese Unie in het kader van subsidie overeenkomst nummer 754936.
Houd er rekening mee dat dit de bètaversie van het COMPAR-EU-platform is. Het bevat nu de voltooide resultaten voor Diabetes Type 2 en gedurende de zomer van 2022 zullen de resultaten voor obesitas, COPD en hartfalen worden voltooid. Ook wordt het platform de komende maanden uitgebreid en verbeterd.