Fil d'Ariane
Documents et Média
Extensions of the probabilistic ranking metrics of competing treatments in network meta-analysis to reflect clinically important relative differences on many outcomes
Extensions of the probabilistic ranking metrics of competing treatments in network meta-analysis to reflect clinically important relative differences on many outcomes
Version 1.0 Approuvé- Type de document
- EXTERNAL_DOCUMENT
- Extension
- png
- Taille
- 279 Ko
- Modifié
- 21/10/22 13:57 par mir mir
- Créé(e)
- 21/10/22 13:57 par mir mir
- Localisation
- PUBLIC
- Notations
-
-
Version 1.0Par mir mir, sur 21/10/22 13:57Log Pas de changement
Résumé
One of the key features of network meta-analysis is ranking of interventions according to outcomes of interest. Ranking metrics are prone to misinterpretation because of two limitations associated with the current ranking methods. First, differences in relative treatment effects might not be clinically important and this is not reflected in the ranking metrics. Second, there are no established methods to include several health outcomes in the ranking assessments. To address these two issues, we extended the P-score method to allow for multiple outcomes and modified it to measure the mean extent of certainty that a treatment is better than the competing treatments by a certain amount, for example, the minimum clinical important difference. We suggest to present the tradeoff between beneficial and harmful outcomes allowing stakeholders to consider how much adverse effect they are willing to tolerate for specific gains in efficacy. We used a published network of 212 trials comparing 15 antipsychotics and placebo using a random effects network meta-analysis model, focusing on three outcomes; reduction in symptoms of schizophrenia in a standardized scale, all-cause discontinuation, and weight gain.
Le projet COMPAR-EU a été financé par le programme de recherche et d'innovation Horizon 2020 de l'Union européenne dans le cadre de la convention de subvention n° 754936.
Veuillez noter qu'il s'agit de la version bêta de la plateforme COMPAR-EU. Il comprend désormais les résultats complets concernant le diabète et, au cours de l'été 2022, les résultats concernant l'obésité, la BPCO ainsi que l'insuffisance cardiaque seront complétés. La plateforme sera également étendue et améliorée pendant les mois à venir.