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COMPAR-EU Web RCTs

Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals with Type 2 Diabetes One-year results of the Look AHEAD trial

Author: Espeland, M. Country/countries: N/A Number of patients participating in the study: 5145 This study was focused on patients living with Type 2 Diabetes Mellitus
Intervention analysed in the study: Social support delivered in groups Intervention components: E+SS+G
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Setting of implementation: Outpatient care (hospital) Professionals delivering the intervention: Educator Targeted self-management behaviours: Condition-specific behaviours, Eating behaviours, Physical activity /exercise, Self-monitoring, Smoking cessation or reduction
Intervention analysed in the study: Emotional-based behavioural techniques and social support delivered in groups Intervention components: E+EB+SS+G
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Setting of implementation: Outpatient care (hospital) Professionals delivering the intervention: Educator Targeted self-management behaviours: Condition-specific behaviours, Eating behaviours, Physical activity /exercise, Self-monitoring, Smoking cessation or reduction

Outcomes measured in the study

Desenlace Medida Tool
Physical activity Physical activity N/A
Weight (management) Weight (Kgs/lbs) N/A

Patient characteristics

Age: 58.7 years (+/- a standard deviation of 6.8) Gender: 59.4% female Time since diagnosis of Type 2 Diabetes Mellitus: N/A Severity of the disease: 7.3 (+/- a standard deviation of 1.2) Multi-morbidity: N/A
  • Number of co-morbidities: 1.0

Level of health literacy: N/A
  • Tool: N/A

Socio-economic characteristics: N/A

Risk of Bias of this study

Desenlace Random sequence generation Allocation concealment Blinding performance Blinding detection objective outcomes assessment Attrition incomplete outcome Incorrect statistical methods Recruitment bias Selective outcome reporting
Physical activity - Physical activity
Weight (management) - Weight (Kgs/lbs)

Other publications associated with this study

Targeting weight loss interventions to reduce cardiovascular complications of type 2 diabetes: a machine learning-based post-hoc analysis of heterogeneous treatment effects in the Look AHEAD trial Enlace: 10.1016/s2213-8587(17)30176-6 One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the look AHEAD study Enlace: 10.1038/oby.2011.315 Effect of improved fitness beyond weight loss on cardiovascular risk factors in individuals with type 2 diabetes in the Look AHEAD study Enlace: 10.1177/2047487312462823 A long-term intensive lifestyle intervention and physical function: the look AHEAD Movement and Memory Study Enlace: 10.1002/oby.20944 Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes Enlace: 10.1007/s11883-014-0457-6 Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study Enlace: 10.1002/oby.20662 Effects of a long-term lifestyle modification programme on peripheral neuropathy in overweight or obese adults with type 2 diabetes: the Look AHEAD study Enlace: 10.1007/s00125-017-4253-z Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the look AHEAD study Enlace: 10.1002/oby.21005 The Look AHEAD Trial: Implications for Lifestyle Intervention in Type 2 Diabetes Mellitus Enlace: 10.1016/j.pcad.2015.04.002 Nudging people with Type 2 diabetes towards better self-management through personalized risk communication: A pilot randomized controlled trial in primary care Enlace: 10.1002/edm2.22 Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes Enlace: 10.1111/jsr.12559 Body image changes associated with participation in an intensive lifestyle weight loss intervention Enlace: 10.1038/oby.2010.276 Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: Four-year results of the look AHEAD trial Enlace: 10.1001/archinternmed.2010.334 Effect of intensive lifestyle intervention on sexual dysfunction inwomen with type 2 diabetes: Results from an ancillary look ahead study Enlace: 10.2337/dc13-0315 Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes Enlace: 10.1016/S0197-2456(03)00064-3 Baseline characteristics of the randomized cohort from the Look AHEAD (Action for Health in Diabetes) Research Study Enlace: 10.3132/dvdr.2006.031 Four-Year Weight Losses in the Look AHEAD Study: Factors Associated with Long-Term Success Enlace: 10.1038/oby.2011.230