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The IIRSS uses a Likert scale ranging from one (not very much) to seven (very much), patients rated the degree of interference caused by their illness or its treatment with 13 aspects of their lives. These domains are: health, diet, work, active and passive recreation, financial situation, relationship with spouse, sex life, family and other social relations, self-expression/selfimprovement, religious expression, and community/civic involvement. Individual item ratings and the sum across ratings are obtained. The total scale has a range of 13 (minimum intrusiveness) to 91 (extreme intrusiveness).