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Misuse of the sign test in narrative synthesis of evidence
- Document Type
- EXTERNAL_DOCUMENT
- Extension
- png
- Size
- 488 KB
- Modified
- 24/10/22 12:03 by mir mir
- Created
- 24/10/22 12:03 by mir mir
- Location
- PUBLIC
- Ratings
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Version 1.0By mir mir, on 24/10/22 12:03No Change Log
Abstract
In narrative synthesis of evidence, it can be the case that the only quantitative measures available concerning the efficacy of an intervention is the direction of the effect, that is, whether it is positive or negative. In such situations, the sign test has been proposed in the literature and in recent Cochrane guidelines as a way to test whether the proportion of positive effects is favorable. I argue that the sign test is inappropriate in this context as the data are not generated according to the binomial distribution it employs. I demonstrate possible consequences for both hypothesis testing and estimation via hypothetical examples.
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The COMPAR-EU project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 754936.
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The COMPAR-EU project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 754936.
Please consider, this is the Beta version of the COMPAR-EU platform. The platform will be expanded and improved in the next months.